The design of port layouts and (offshore) terminals suitable for LNG-carriers has to meet exceptionally high safety standards. All responsible parties aim at the design of an inherently safe offloading system either on-shore or offshore. In a port area a careful selection of the terminal location is combined with the definition of strict nautical procedures. Offshore all the focus is on the operational procedures and the interfacing connections.In this paper we like to discuss two typical examples of a safety study combined with a design of operations. The design of the operation aims at obtaining a safety level that is equal or higher than predicted in the safety study. Especially when dealing with LNG this is an important goal. One study discussed in this paper is related to offshore operations (Case 1) and one for a typical port (Case 2).